Prof. Dr. med. Peter Schirmacher

Professor of Pathology (C4) and Director, Institute of Pathology, Heidelberg

Professor of Pathology (C3), Deputy Director, Institute of Pathology, Cologne

Board Certification Molecular Pathology

Board Certification Pathology

Research Associate, Institute of Pathology, University of Mainz

Postdoctoral Research Fellowship (DFG); Liver Research Center, Albert Einstein College of Medicine, New York

Research Associate, Institute of Pathology, University of Mainz

Habilitation (Pathology), University of Mainz

PhD-Study (Molecular Biology), Liver Research Center, Albert Einstein College of Medicine, New York

MD-Thesis, Institute of Physiology, University of Mainz

Study of Medicine, University of Mainz

Member of the Leopoldina, German National Academy of Sciences

Boehringer Ingelheim Award

Johannes Gutenberg Award

Since 2015 Board member European Society of Pathology (ESP)

Board member National Center of Tumor Diseases (NCT)

Board Member German Telematics Platform (TMF

Board Member International Liver Cancer Association (ILCA)

Board Member German Liver Foundation

Member and Speaker (2008-2012) of Section 2 (Cancer and Stem Cell Research), German Research Foundation (DFG)

Board Member German Association for Study of the Liver (President 2008-2009)

Board Member German Association of Pathology (DGP)

Chairman German Society of Pathology

President German Society of Pathology

President International Laennec Society of Liver Pathology

Founder and Coordinator of the centralized BiomaterialBank Heidelberg BMBH

Principle Investigator and Coordinator of Biobanking Platforms, GermanConsortium for Translational Cancer Research (DKTK) and German Center for Infectious Diseases Research (DZIF)

Coordinator of the SFB/TR77 “Liver Cancer” (DFG)

Co-Founder and Speaker of the Advisory Board 'Tissue Imaging and Analysis Center’ (TIGA), Heidelberg

Founder and Speaker ‘Tissue Bank of the National Center of Tumor Diseases

Founder and Speaker ‘Working Group Tissue Banks of the German Cancer Centers’

Managing board Tumorzentrum Heidelberg/Mannheim

Managing board ‘Center for Molecular Medicine Cologne’ (CMMC)

Managing board DFG-SFB 519

1. Mogler C, König C, Wieland M, Runge A, Besemfelder E, Komljenovic D, Longerich T, Schirmacher P, Augustin HG. (2017) Hepatic stellate cells limit hepatocellular carcinoma progression through the orphan receptor endosialin. EMBO Mol Med. 9(6):741-749

2. Gdynia G, Sauer SW, Kopitz J, Fuchs D, Duglova K, Ruppert T, Miller M, Pahl J, Cerwenka A, Enders M, Mairbäurl H, Kamiński MM, Penzel R, Zhang C, Fuller JC, Wade RC, Benner A, Chang-Claude J, Brenner H, Hoffmeister M, Zentgraf H, Schirmacher P, Roth W. (2016) The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration. Nat Commun 7:10764. (Publication received the Novartis Award 2016 and the Landesforschungspreis Baden-Württemberg 2016)

3. Ploeger C, Waldburger N, Fraas A, Goeppert B, Pusch S, Breuhahn K, Wang XW, Schirmacher P, Roessler S (2016) Chromosome 8p tumor suppressor genes SH2D4A and SORBS3 cooperate to inhibit interleukin-6 signaling in hepatocellular carcinoma. Hepatology 64(3):828-42.

4. Samarin J, Laketa V, Malz M, Roessler S, Stein I, Horwitz E, Singer S, Dimou E, Cigliano A, Bissinger M, Falk CS, Chen X, Dooley S, Pikarsky E, Calvisi DF, Schultz C, Schirmacher P, Breuhahn K. (2016) PI3K/AKT/mTOR-dependent stabilization of oncogenic far-upstream element binding proteins in hepatocellular carcinoma cells. Hepatology 63(3):813-26.

5. Rudalska R, Dauch D, Longerich T, McJunkin K, Wuestefeld T, Kang TW, Hohmeyer A, Pesic M, Leibold J, von Thun A, Schirmacher P, Zuber J, Weiss KH, Powers S, Malek NP, Eilers M, Sipos B, Lowe SW, Geffers R, Laufer S, Zender L (2014) In vivo RNAi screening identifies mechanisms of Sorafenib resistance in liver cancer. Nat Med 20(10):1138-46.

6. Pellegrino R, Calvisi DF, Neumann O, Kolluru V, Wesely J, Chen X, Wang C, Wuestefeld T, Ladu S, Elgohary N, Bermejo JL, Radlwimmer B, Zörnig M, Zender L, Dombrowski F, Evert M, Schirmacher P, Longerich T. (2014) EEF1A2 inactivates p53 by way of PI3K/AKT/mTORdependent stabilization of MDM4 in hepatocellular carcinoma. Hepatology 59(5):1886-99.

7. Wuestefeld T, Pesic M, Rudalska R, Dauch D, Longerich T, Kang TW, Yevsa T, Heinzmann F, Hoenicke L, Hohmeyer A, Potapova A, Rittelmeier I, Jarek M, Geffers R, Scharfe M, Klawonn F, Schirmacher P, Malek NP, Ott M, Nordheim A, Vogel A, Manns MP, Zender L (2013) A Direct in vivo RNAi screen identifies MKK4 as a key regulator of liver regeneration. Cell 153(2):389-401.

8. Tschaharganeh DF, Chen X, Latzko P, Malz M, Gaida MM, Felix K, Ladu S, Singer S, Pinna F, Gretz N, Sticht C, Tomasi ML, Delogu S, Evert M, Fan B, Ribback S, Jiang L, Brozzetti S, Bergmann F, Dombrowski F, Schirmacher P, Calvisi DF, Breuhahn K (2013) Yes-associated protein up-regulates Jagged-1 and activates the Notch pathway in human hepatocellular carcinoma. Gastroenterology 144(7):1530-1542.e12.

9. Singer S, Zhao R, Barsotti AM, Ouwehand A, Fazollahi M, Coutavas E, Breuhahn K, Neumann O, Longerich T, Pusterla T, Powers MA, Giles KM, Leedman PJ, Hess J, Grunwald D, Bussemaker HJ, Singer RH, Schirmacher P, Prives C (2012) Nuclear pore component Nup98 is a potential tumor suppressor and regulates posttranscriptional expression of select p53 target genes. Mol Cell 48(5):799-810.

10.Kang TW, Yevsa T, Woller N, Hoenicke L, Wuestefeld T, Dauch D, Hohmeyer A, Gereke M, Rudalska R, Potapova A, Iken M, Vucur M, Weiss S, Heikenwalder M, Khan S, Gil J, Bruder D, Manns M, Schirmacher P, Tacke F, Ott M, Luedde T, Longerich T, Kubicka S, Zender L (2011) Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. Nature 479(7374):547-51.

Molecular and morphological digestive tract carcinogenesis (especially liver and pancreas); Tumorigenicrole of growth factor mediated signaling processes; Chronic liver diseases and their role in hepat-carcinogenesis; molecular pathological diagnostics; Biobanking; VirtualMicroscopy

Journal  of  Hepatology  (Associate  Editor),  Hepatology,  Virchows Archive,LiverCancer, Pathology Research and Practice, Pathologe